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KMID : 0606920190270040381
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Biomolecules & Therapeutics
2019 Volume.27 No. 4 p.381 ~ p.385
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4’-O-β-D-Glucosyl-5-O-Methylvisamminol Attenuates Pro-Inflammatory Responses and Protects against Oxidative Damages
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Yoo Ok-Kyung
Keum Young-Sam
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Abstract
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We attempted to examine anti-inflammatory and anti-oxidant effects of 4’-O-β-D-glucosyl-5-O-methylvisamminol (GOMV), the first epigenetic inhibitor of histone phosphorylation at Ser10. While GOMV did not affect the viability of murine macrophage RAW 264.7 cells, it significantly suppressed lipopolysaccharide (LPS)-induced generation of prostaglandin E2 (PGE2) and nitric oxide (NO) through transcriptional inhibition of cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS). GOMV also scavenged free radicals in vitro, increased NF-E2-related factor 2 (NRF2), and activated antioxidant response element (ARE), thereby resulting in the induction of phase II cytoprotective enzymes in human keratinocyte HaCaT cells. Finally, GOMV significantly protected HaCaT cells against 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced oxidative intracellular damages. Together, our results illustrate that GOMV possesses anti-inflammatory and anti-oxidant activity.
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KEYWORD
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4’-O-β-D-glucosyl-5-O-methylvisamminol (GOMV), Reactive oxygen species (ROS), NF-E2-related factor 2 (NRF2), Antioxidant response element (ARE)
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